"Ikaw ang Pag-ibig" tackles the story of a woman named Vangie Cruz (Ina Feleo) who is called upon to be a donor for his only brother Fr. Johnny (Marvin Agustin), a newly ordained priest who happens to be diagnosed of Acute Myeloid Leukemia. However, she declines due to clinical phobia for medical procedures that were triggered by a failed attempt of abortion many years before. She meets Dr. Joey Lucas (Jomari Yllana) with whom she has a love child and they eventually get married. Suddenly Vangie and her family caved in with her brother’s condition. Through their struggle, they gravitate to their faith in Ina, The Our Lady of Penafrancia. A miracle comes not through the cure of Fr. Johnny’s illness, but through the family’s reconciliation and a new found faith in hope and love.