"Beauty And The Bestie" centers on Erika (Vice Ganda), a gay photographer, and his former best friend, special agent Emman (Coco Martin). Emman offers Erika a secret mission to post as the missing Miss Uzeklovakia in the Miss Uniworld 2015 pageant to prevent the latter’s recluse country from waging a possible world war. As Erika accepts the mission, the former BFFs find themselves entangled in the crazy world of beauty pageants in their action-packed adventure. As they race against time, Erika and Emman find themselves in an awkward situation that forces them to rekindle a peculiar flame in their past.