Teen heartthrob Billy Fernandez (Daniel Padilla) is having a concert happening on December 21, 2012. With this, a video making contest is launched for Billy’s fans to have a chance to win VIP tickets to the young celebrity’s concert. Contestants must answer this hypothetical question: “Ano ang gagawin mo bago magunaw ang mundo?” Jane (Kathryn Bernardo), a hardcore fan of Billy, decides to join the contest. She is determined to win the concert although would also be the day that her annual family reunion takes place. She meets people from different walks of life who have various stories to share all anchored into the power and magic of LOVE. Virgie (Pokwang), a 40 year-old virgin, breaks out of her shell and decides to lose her virginity. With the help of her gay friend Melo (John Lapus) they search for a gigolo in an escort site who can potentially give Virgie the service she is looking for and they find this hot model-esque guy named Charles (Sam Milby). Just when the hopeless romantic Barbara (Maja Salvador) learns to accept that she can only love his commitment-resistant boss, Ken (Diether Ocampo) from a distance, a cuddly little baby is found in Ken's hotel room. Barbara finds this an opportunity for Ken to open up his heart. As they wait for the DNA result, will the outcome bring about a new beginning for the two of them? Verna (Angelica Pangabiban) goes back to Vietnam for a vacation after learning her husband’s infidelity. There, she meets a Filipino waiter named Elvis (John Lloyd Cruz). Vietnam and Elvis has become Verna’s refuge, but an escape can only do so much. Verna will have to find the courage to face her inevitable choice. Belle (Bea Alonzo) is in love with her long time best friend Butch (Zanjoe Marudo). Butch is a gay and is set to live in Milan with his boyfriend. She pursues to make Butch realize that the love she has for him is worth staying, however, in the same way, brings their friendship to a test that will define the true meaning of their love for each other. Pipoy (Piolo Pascual), a 35 year old mentally-challenged man, spends each day with Jomar (Zaijian Jaranilla), a 10 year old orphan. The ultimate test of their friendship comes when Ayie (Xyriel Manabat), a nine-year old girl enters their lives. Patty (Kim Chiu), a driven and young account executive, has to save her job. Her boss is threatening to fire her unless she finds this guy who becomes an instant celebrity for rescuing his neighbors from a fire fiasco. Apparently, this anonymous underwear hero is her ex-boyfriend Alvin (Gerald Anderson) whom she hurt in the past.